Comparison of Bioactive Compound Content in Carica papaya and Manihot esculenta Leaf Extract Based on FTIR (Fourier Transform Infrared) Analysis in Traditional Dengue Hemorrhagic Fever (DHF) Therapy

  • Sistani Huzainiyah Fakultas Sains dan Teknologi, UIN Sunan Ampel Surabaya
  • Elsa Defitri Fakultas Sains dan Teknologi, UIN Sunan Ampel Surabaya
  • Funsu Andiarna Fakultas Sains dan Teknologi, UIN Sunan Ampel Surabaya
  • Eva Agustina Fakultas Sains dan Teknologi, UIN Sunan Ampel Surabaya
  • Risa Purnamasari Fakultas Psikologi dan Kesehatan, UIN Sunan Ampel Surabaya
  • Nova Lusiana Fakultas Sains dan Teknologi, UIN Sunan Ampel Surabaya
  • Funsu Andirna Fakultas Psikologi dan Kesehatan, UIN Sunan Ampel Surabaya
  • Irul Hidayat Fakultas Psikologi dan Kesehatan, UIN Sunan Ampel Surabaya
DOI: https://doi.org/10.29080/icoshpro.v4i1.3495
Keywords: Papaya leaves, Cassava leaves, FTIR, Bioactive compounds, DHF

Abstract

Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by the dengue virus transmitted by Aedes aegypti, often leading to thrombocytopenia. Herbal-based traditional therapies, such as papaya leaves (Carica papaya L.) and cassava leaves (Manihot esculenta Crantz), are considered potential supportive treatments. This study aims to compare the bioactive compounds of both plants through phytochemical screening and Fourier Transform Infrared (FTIR) analysis. The phytochemical results revealed that papaya leaves contain alkaloids, flavonoids, phenolics, tannins, saponins, steroids, and triterpenoids, while cassava leaves contain alkaloids, flavonoids, phenolics, tannins, and triterpenoids. FTIR analysis identified functional groups O–H, C=O, aromatic C=C, C–H, and C–O, indicating the presence of flavonoids, polyphenols, and glycosides. Pharmacologically, papaya leaf extract demonstrated greater potential as it has been clinically proven to increase platelet count through hematopoiesis stimulation and gene regulation. In contrast, cassava leaf extract exhibited antioxidant and hematopoietic potential but with limited clinical evidence. Therefore, papaya leaves are considered more effective as a traditional supportive therapy to aid
platelet recovery in DHF patients.

Published
2025-10-20
How to Cite
Sistani Huzainiyah, Elsa Defitri, Funsu Andiarna, Eva Agustina, Risa Purnamasari, Nova Lusiana, Funsu Andirna, & Irul Hidayat. (2025). Comparison of Bioactive Compound Content in Carica papaya and Manihot esculenta Leaf Extract Based on FTIR (Fourier Transform Infrared) Analysis in Traditional Dengue Hemorrhagic Fever (DHF) Therapy. International Conference on Sustainable Health Promotion, 4(1), 429-439. https://doi.org/10.29080/icoshpro.v4i1.3495
Issue
Vol. 4 No. 1 (2025): ICOSHPRO 2025
Section
Articles

Copyright (c) 2025 Sistani Huzainiyah, Elsa Defitri, Funsu Andiarna, Eva Agustina, Risa Purnamasari, Nova Lusiana, Funsu Andirna, Irul Hidayat

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